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“This breaks down the definition of model organism,” says Wang, a postdoctoral researcher in Jaenisch’s lab. “So now, even with limited resources, any animal with established embryo manipulation procedures could be the subject of genome engineering. With many of the animals’ genomes that have been sequenced, we could use this technology to establish efficient genetic manipulations in more species, to study the unique biology of each, and to learn more about evolution.”
Thus, Wang, Yang, and Shivalila have used CRISPR/Cas to create mouse models only, but the team is excited broaden its application to other animals.